"Physical Activity and Exercise Therapy Benefit More Than Just Symptoms and Impairments in People With Hip and Knee Osteoarthritis."
Exercise can help to fight the vicious cycle of chronic inflammation in patients with osteoarthritis or rheumatoid arthritis. Exercise can regulate myokines, a protein facilitating anti-inflammatory function. Even further long-term health benefits of exercise improve comorbidities and cardiovascular risk factors. We thought that physical activity might aggravate inflammatory pathways, exercise is now appeared to be recommended therapy for folks with joint degeneration. It is time to change our myth about exercise. Exercise can actually prevent "vicious cycle" of chronic systemic inflammation (see pictures below, from JOSPT).
According to JOSPT, "In osteoarthritis, local inflammation of the synovial membranes of the knee (or hip) joint can lead to chronic systemic inflammation, which can predispose one to conditions that contribute to functional impairments, including insulin resistance, dyslipidemia, endothelial dysfunction, accelerated atherosclerosis, neurodegeneration, muscle atrophy, and anemia. Lack of physical activity and exercise, in turn, can cause the accumulation of visceral fat and thereby exacerbate inflammation and promote metabolic disorders, atherosclerosis, and the development of a number of chronic diseases. In a positive feedback loop, this will negatively affect cardiovascular performance and the ability to be physically active and exercise. Abbreviation: GLUT-4, glucose transporter type 4, insulin responsive."
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